Chronic periodontitis may contribute to Alzheimer’s disease through systemic inflammation, oral pathogens, and neurodegenerative mechanisms. Research suggests periodontal infections can amplify Alzheimer’s risk — with some studies reporting a ~2-fold elevation — through systemic cytokines and the potential translocation of oral pathogens like Porphyromonas gingivalis into the brain. Vijay Kumar Malesu · News-Medical.net